Wissenswertes zum Thema Kurkuma
Es gibt kaum eine andere Heilpflanze, zu der so viele Studien existieren wie zu Kurkuma bzw. dessen Inhaltsstoff Curcumin. Dabei werden diverse Indikationsgebiete aufgegriffen und untersucht, welchen gesundheitlichen Nutzen Curcumin erbringen kann.
Die Seite „mitunsgesund“ gibt hier eine nützliche Übersicht, in welchen Bereichen die Studienlage besonders aussagekräftig ist: mitunsgesund.info Darüber hinaus werden beinahe täglich neue Studien, teilweise Labor- aber auch des Öfteren Humanstudien veröffentlicht.
Anbei findest du eine Auflistung einiger relevanter wissenschaftlicher Studien. Abgerufen werden können alle Studien auf der Datenbank Pubmed: www.ncbi.nlm.nih.gov/pubmed. Eingegeben werden sollten hier die Begriffe „Curcumin“, „Turmeric“ oder „Curcuma longa".
Bioverfügbarkeit und Pharmakokinetik
Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. S. S. R. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(4), 353–356.
Kuroda, M., Mimaki, Y., Nishiyama, T., Mae, T., Kishida, H., Tsukagawa, M., … Kitahara, M. (2005). Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice. Biological & Pharmaceutical Bulletin, 28(5), 937–939.
Pari, L., & Murugan, P. (2007). Changes in glycoprotein components in streptozotocin–nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa. Plant Foods for Human Nutrition (Dordrecht, Netherlands), 62(1), 25–29.
Gonzales, A. M., & Orlando, R. A. (2008). Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutrition and Metabolism, 5(1).
Yu, Y., Hu, S., & Yan, H. (2008). [The study of insulin resistance and leptin resistance on the model of simplicity obesity rats by curcumin]. Zhonghua Yu Fang Yi Xue Za Zhi, 42(11), 818–822.
Weisberg, S. P., Leibel, R., & Tortoriello, D. V. (2008). Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology, 149(7), 3549–3558.
Ejaz, A., Wu, D., Kwan, P., & Meydani, M. (2009). Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice. Journal of Nutrition, 139(5), 919–925.
Lee, Y. K., Lee, W. S., Hwang, J. T., Kwon, D. Y., Surh, Y. J., & Park, O. J. (2009). Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. Journal of Agricultural and Food Chemistry, 57(1), 305–310.
Wang, S. L., Ying, L., Ying, W., Chen, Y. F., Na, L. X., Li, S. T., & Sun, C. H. (2009). Curcumin, a potential inhibitor of Up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. Biomedical and Environmental Sciences, 22(1), 32–39.
Nwozo, S., Adaramoye, O., & Ajaiyeoba, E. (2009). Oral administration of extract from Curcuma longa lowers blood glucose and attenuates alloxan-induced hyperlipidemia in diabetic rabbits. Pakistan Journal of Nutrition, 8(5), 625–628.
Feng, D., Ohlsson, L., & Duan, R.-D. (2010). Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression. Lipids in Health and Disease, 9, 40.
Kim, M., & Kim, Y. (2010). Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutrition Research and Practice, 4(3), 191–5.
Wickenberg, J., Ingemansson, S. L., & Hlebowicz, J. (2010). Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutrition Journal, 9, 43.
Alappat, L., & Awad, A. B. (2010). Curcumin and obesity: Evidence and mechanisms. Nutrition Reviews, 68(12), 729–738.
Dong, S. Z., Zhao, S. P., Wu, Z. H., Yang, J., Xie, X. Z., Yu, B. L., & Nie, S. (2011). Curcumin promotes cholesterol efflux from adipocytes related to PPARgamma-LXRalpha-ABCA1 passway. Molecular and Cellular Biochemistry, 358(1–2), 281–285.
El-Azab, M. F., Attia, F. M., & El-Mowafy, A. M. (2011). Novel role of curcumin combined with bone marrow transplantation in reversing experimental diabetes: Effects on pancreatic islet regeneration, oxidative stress, and inflammatory cytokines. European Journal of Pharmacology, 658(1), 41–48.
Xie, X. Y., Kong, P. R., Wu, J. F., Li, Y., & Li, Y. X. (2012). Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes. Phytomedicine, 20(1), 3–8.
Xie, X. Y., Kong, P. R., Wu, J. F., Li, Y., & Li, Y. X. (2012). Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes. Phytomedicine, 20(1), 3–8.
Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., & Jirawatnotai, S. (2012). Curcumin extract for prevention of type 2 diabetes. Diabetes Care, 35(November), 2121–2127.
Prathapan, a., Krishna, M. S., Lekshmi, P. C., Raghu, K. G., & Menon, a. N. (2012). Modulation of adipogenesis and glucose uptake by Curcuma longa extract in 3T3L1 and L6 cell lines – An in vitro study. Asian Pacific Journal of Tropical Disease, 2, 163–165.
Alzheimer (Neurodegenerative Erkrankungen)
Eckert, G. P., Schiborr, C., Hagl, S., Abdel-Kader, R., Müller, W. E., Rimbach, G., & Frank, J. (2013). Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8. Neurochemistry International, 62(5), 595–602.
Wang, X., Kim, J.-R., Lee, S.-B., Kim, Y.-J., Jung, M. Y., Kwon, H.-W., & Ahn, Y.-J. (2014). Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models. BMC Complementary and Alternative Medicine, 14(1), 88.
Wang, X., Kim, J.-R., Lee, S.-B., Kim, Y.-J., Jung, M. Y., Kwon, H.-W., & Ahn, Y.-J. (2014). Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models. BMC Complementary and Alternative Medicine, 14(1), 88.
Depressionen
Xu, Y., Ku, B. S., Yao, H. Y., Lin, Y. H., Ma, X., Zhang, Y. H., & Li, X. J. (2005). The effects of curcumin on depressive-like behaviors in mice. European Journal of Pharmacology, 518(1), 40–46.
Xu, Y., Ku, B., Tie, L., Yao, H., Jiang, W., Ma, X., & Li, X. (2006). Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Research, 1122(1), 56–64.
Kulkarni, S. K., Bhutani, M. K., & Bishnoi, M. (2008). Antidepressant activity of curcumin: Involvement of serotonin and dopamine system. Psychopharmacology, 201(3), 435–442.
Kulkarni, S. K., Dhir, A., & Akula, K. K. (2009). Potentials of Curcumin as an Antidepressant. The Scientific World JOURNAL, 9, 1233–1241.
Kulkarni, S. K., Dhir, A., & Akula, K. K. (2009). Potentials of Curcumin as an Antidepressant. The Scientific World JOURNAL, 9, 1233–1241.
Sookram, C., Daya, R., Tan, M., Mah, J., & Mishra, R. K. (2012). Curcumin: Implications in the treatment of central nervous system disease. Curcumin: Biosynthesis, Medicinal Uses and Health Benefits.
Bergman, J., Miodownik, C., Bersudsky, Y., Sokolik, S., Lerner, P. P., Kreinin, A., … Lerner, V. (2013). Curcumin as an add-on to antidepressive treatment: A randomized, double-blind, placebo-controlled, pilot clinical study. Clinical Neuropharmacology, 36(3), 73–77.
Lopresti, A. L., Maes, M., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014). Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study. Journal of Affective Disorders, 167, 368–375.
Sanmukhani, J., Satodia, V., Trivedi, J., Patel, T., Tiwari, D., Panchal, B., … Tripathi, C. B. (2014). Efficacy and safety of curcumin in major depressive disorder: A randomized controlled trial. Phytotherapy Research, 28(4), 579–585.
Yu, J.-J., Pei, L.-B., Zhang, Y., Wen, Z.-Y., & Yang, J.-L. (2015). Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Journal of Clinical Psychopharmacology, 35(4), 406–410.
Al-Karawi, D., Al Mamoori, D. A., & Tayyar, Y. (2015). The role of curcumin administration in patients with major depressive disorder: mini meta-analysis of clinical trials. Phytotherapy Research, 183(October 2015), 175–183.
Rheumatische Erkrankungen
Funk, J. L., Oyarzo, J. N., Frye, J. B., Chen, G., Lantz, R. C., Jolad, S. D., … Timmermann, B. N. (2006). Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. Journal of Natural Products, 69(3), 351–355.
Oh, S., Kyung, T.-W., & Choi, H.-S. (2008). Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells. Molecules and Cells, 26(5), 486–489.
Clutterbuck, A. L., Mobasheri, A., Shakibaei, M., Allaway, D., & Harris, P. (2009). Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Annals of the New York Academy of Sciences, 1171, 428–35.
Mathy-Hartert, M., Jacquemond-Collet, I., Priem, F., Sanchez, C., Lambert, C., & Henrotin, Y. (2009). Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflammation Research: Official Journal of the European Histamine Research Society … [et Al.], 58(12), 899–908.
Funk, J. L., Frye, J. B., Oyarzo, J. N., Zhang, H., & Timmermann, B. N. (2010). Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.). Journal of Agricultural and Food Chemistry, 58(2), 842–849.
Taty Anna, K., Elvy Suhana, M. R., Das, S., Faizah, O., & Hamzaini, A. H. (2011). Anti-inflammatory effect of Curcuma longa (turmeric) on collagen-induced arthritis: an anatomico-radiological study. La Clinica Terapeutica, 162(3), 201–207.
Chandran, B., & Goel, A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy Research: PTR, 26(11), 1719–25.
Sun, J., Zhao, Y., & Hu, J. (2013). Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice. PloS One, 8(6), e67078.
Shehzad, A., Rehman, G., & Lee, Y. S. (2013). Curcumin in inflammatory diseases. BioFactors, 39(1), 69–77.
Kuptniratsaikul, V., Dajpratham, P., Taechaarpornkul, W., Buntragulpoontawee, M., Lukkanapichonchut, P., Chootip, C., … Laongpech, S. (2014). Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study. Clinical Interventions in Aging, 9, 451–458.
Belcaro, G., Dugall, M., Luzzi, R., Ledda, A., Pellegrini, L., Cesarone, M. R., … Errichi, M. (2014). Meriva(R)+Glucosamine versus Condroitin+Glucosamine in patients with knee osteoarthritis: an observational study. Eur Rev Med Pharmacol Sci, 18(24), 3959–3963.
Daily, J. W., Yang, M., & Park, S. (2016). Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of Medicinal Food, 19(8), 717–729.
Lee, J. H., Oh, J.-H., & Lee, Y.-J. (2012). Biliary excretion of curcumin is mediated by multidrug resistance-associated protein 2. Biological & Pharmaceutical Bulletin, 35(5), 777–780.
Patra, D., Ahmadieh, D., & Aridi, R. (2013). Study on interaction of bile salts with curcumin and curcumin embedded in dipalmitoyl-sn-glycero-3-phosphocholine liposome. Colloids and Surfaces. B, Biointerfaces, 110, 296–304.
Patra, D., Ahmadieh, D., & Aridi, R. (2013). Study on interaction of bile salts with curcumin and curcumin embedded in dipalmitoyl-sn-glycero-3-phosphocholine liposome. Colloids and Surfaces. B, Biointerfaces, 110, 296–304.
Jaruga, E., Salvioli, S., Dobrucki, J., Chrul, S., Bandorowicz-Pikuła, J., Sikora, E., … Bartosz, G. (1998). Apoptosis-like, reversible changes in plasma membrane asymmetry and permeability, and transient modifications in mitochondrial membrane potential induced by curcumin in rat thymocytes. FEBS Letters, 433(3), 287–293.
Plummer, S. M., Holloway, K. a, Manson, M. M., Munks, R. J., Kaptein, a, Farrow, S., & Howells, L. (1999). Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene, 18(44), 6013–6020.
Ramírez-Tortosa, M. C., Mesa, M. D., Aguilera, M. C., Quiles, J. L., Baró, L., Ramirez-Tortosa, C. L., … Gil, A. (1999). Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis, 147(2), 371–378.
Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., … Kurzrock, R. (2008). Phase II trial of curcumin in patients with advanced pancreatic cancer. Clinical Cancer Research, 14(14), 4491–4499.
Badmaev, V., Aggarwal, B. B., Fiala, M., Majeed, M., Golombick, T., & Diamond, T. (2008). Curcuminoids from Curcuma longa in the fight against cancer and age related disorders. Australian Journal of Medical Herbalism, 20(2), 57–63
Badmaev, V., Aggarwal, B. B., Fiala, M., Majeed, M., Golombick, T., & Diamond, T. (2008). Curcuminoids from Curcuma longa in the fight against cancer and age related disorders. Australian Journal of Medical Herbalism, 20(2), 57–63
Kuo, C.-L., Wu, S.-Y., Ip, S.-W., Wu, P.-P., Yu, C.-S., Yang, J.-S., … Chung, J.-G. (2011). Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses. International Journal of Oncology, 39(2), 319–328.
Liu, H., Liang, Y., Wang, L., Tian, L., Song, R., Han, T., … Liu, L. (2012). In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog. PloS One, 7(10), e48075.
Cho, Y. A., Lee, W., & Choi, J. S. (2012). Effects of curcumin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen, in rats: Possible role of CYP3A4 and P-glycoprotein inhibition by curcumin. Pharmazie.
Gao, X.-F., Li, Q.-L., Li, H.-L., Zhang, H.-Y., Su, J.-Y., Wang, B., … Zhang, A.-Q. (2014). Extracts from Curcuma zedoaria Inhibit Proliferation of Human Breast Cancer Cell MDA-MB-231 In Vitro. Evidence-Based Complementary and Alternative Medicine : ECAM, 2014, 730678.
Henrotin, Y., Gharbi, M., Dierckxsens, Y., Priem, F., Marty, M., Seidel, L., … Castermans, C. (2014). Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial. BMC Complementary and Alternative Medicine, 14, 159.
Henrotin, Y., Gharbi, M., Dierckxsens, Y., Priem, F., Marty, M., Seidel, L., … Castermans, C. (2014). Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial. BMC Complementary and Alternative Medicine, 14, 159.